The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs

Autor:	Y Y, Shugart, D E, Goldgar
Rok vydání:	1997
Předmět:	Male Likelihood Functions Genetic Linkage Genome Human Matched-Pair Analysis Chromosome Mapping Nuclear Family Quantitative Trait Heritable Predictive Value of Tests Humans Female Genetic Testing Lod Score Software
Zdroj:	Genetic epidemiology. 14(6)
ISSN:	0741-0395
Popis:	This paper summarizes the results of searching for evidence of loci contributing to simulated quantitative traits which are associated with a common genetic disease using two multipoint identity by descent (IBD) sharing methods: MIM and MAPMAKER/SIBS. In brief, by varying the lod-score threshold from 1 to 3, we found that MIM and MAPMAKER/SIBS have similar power to detect linkage, but MAPMAKER/SIBS consistently produces a higher number of false positives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a3f9f46340b9c14a3055c4b88dc51719 https://pubmed.ncbi.nlm.nih.gov/9433597 Zobrazit plný text záznamu Plný text