| Autor: |
M R, Mac Gillavry, J G, Lijmer, B J, Sanson, H R, Büller, D P, Brandjes |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Thrombosis and haemostasis. 85(6) |
| ISSN: |
0340-6245 |
| Popis: |
We performed a study in 403 prospectively included patients with suspected pulmonary embolism to compare the accuracy of a combination of the SimpliRED D-dimer assay and an intuitive clinical probability estimate with either one alone. Based on a conjoint diagnostic refer, ence standard, including ventilation-perfusion lung scintigraphy and pulmonary angiography, the prevalence of pulmonary embolism was 31%. We demonstrated a high sensitivity (98%, 95% CI 95-100) and negative predictive value (94%, 95% CI 79-99) for the combination of the two tests. These figures were more favorable than for either test alone. The specificity of the combination was lower (11%, 95% CI 9-12) and consequently the proportion of patients in whom further diagnostic tests would have been avoided was only 8%. We conclude that the combined use of the SimpliRED test and the clinical probability estimate attains a higher sensitivity than either test alone. However, there remains a risk of false negatives and the exclusion efficiency is limited. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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