Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are I

Autor:	Igor, Baburin, Rosanne, Varkevisser, Anja, Schramm, Priyanka, Saxena, Stanislav, Beyl, Phillip, Szkokan, Tobias, Linder, Anna, Stary-Weinzinger, Marcel A G, van der Heyden, Marien, Houtman, Hiroki, Takanari, Malin, Jonsson, Jet H D, Beekman, Matthias, Hamburger, Marc A, Vos, Steffen, Hering
Rok vydání:	2017
Předmět:	Xenopus Action Potentials Arrhythmias Cardiac Ether-A-Go-Go Potassium Channels Evodia Alkaloids Dogs HEK293 Cells Torsades de Pointes Animals Humans Female Myocytes Cardiac Rabbits Drugs Chinese Herbal
Zdroj:	Pharmacological research. 131
ISSN:	1096-1186
Popis:	Evodiae fructus is a widely used herbal drug in traditional Chinese medicine. Evodia extract was found to inhibit hERG channels. The aim of the current study was to identify hERG inhibitors in Evodia extract and to investigate their potential proarrhythmic effects. Dehydroevodiamine (DHE) and hortiamine were identified as I
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a3a0e30d8137616ab18c26a4831a1c5f https://pubmed.ncbi.nlm.nih.gov/29477480 Zobrazit plný text záznamu Full Text from ScienceDirect