A Study on the Presence of Osteopontin and α3β1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation

Autor: Yasaman, Zarrin, Abbas, Bakhteyari, Parvaneh, Nikpour, Fatemeh Sadat, Mostafavi, Nahid, Eskandari, Mohammad, Matinfar, Roshanak, Aboutorabi
Rok vydání: 2020
Předmět:
Zdroj: Journal of Reproduction & Infertility
ISSN: 2228-5482
Popis: Background: Embryo implantation is a critical and multifactorial phenomenon which can be affected by any alteration in molecular micro construction of endometrium. The aim of the current study was to evaluate the effects of diabetes on osteopontin (OPN) and α3β1 integrin proteins level at the time of endometrial receptivity. Methods: Twenty-eight female rats were divided into control, diabetic, pioglitazone-treated and metformin-treated groups. Western blot was performed to determine the OPN and α3β1 integrin proteins in rats’ endometrium at the time of implantation. Data were analyzed by analysis of variance (ANOVA) and p
Databáze: OpenAIRE