| Autor: |
A V, Callaghan, B E L, Morris, I A C, Pereira, M J, McInerney, R N, Austin, J T, Groves, J J, Kukor, J M, Suflita, L Y, Young, G J, Zylstra, B, Wawrik |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Environmental microbiology. 14(1) |
| ISSN: |
1462-2920 |
| Popis: |
Desulfatibacillum alkenivorans AK-01 serves as a model organism for anaerobic alkane biodegradation because of its distinctive biochemistry and metabolic versatility. The D. alkenivorans genome provides a blueprint for understanding the genetic systems involved in alkane metabolism including substrate activation, CoA ligation, carbon-skeleton rearrangement and decarboxylation. Genomic analysis suggested a route to regenerate the fumarate needed for alkane activation via methylmalonyl-CoA and predicted the capability for syntrophic alkane metabolism, which was experimentally verified. Pathways involved in the oxidation of alkanes, alcohols, organic acids and n-saturated fatty acids coupled to sulfate reduction and the ability to grow chemolithoautotrophically were predicted. A complement of genes for motility and oxygen detoxification suggests that D. alkenivorans may be physiologically adapted to a wide range of environmental conditions. The D. alkenivorans genome serves as a platform for further study of anaerobic, hydrocarbon-oxidizing microorganisms and their roles in bioremediation, energy recovery and global carbon cycling. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text