| Autor: |
J A, Simon, D E, Robinson, M C, Andrews, J R, Hildebrand, M L, Rocci, R E, Blake, G D, Hodgen |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Fertility and sterility. 60(1) |
| ISSN: |
0015-0282 |
| Popis: |
To examine the effects of food ingestion and administered dose on the absorption of oral micronized P (Utrogestan; Besins-Iscovesco, Paris, France) and to compare the bioavailability of intramuscular versus oral routes of administration.Prospective, randomized, open label crossover protocol with 7 days between dosages.Academic institution.Fifteen normal postmenopausal women.All subjects participated in three separate protocols: [1] micronized P (200 mg) or placebo under fasting or nonfasting conditions once daily for 5 days; [2] micronized P (100, 200, or 300 mg) once daily under fasting conditions for 5 days; and [3] micronized P (200 mg) or intramuscular P (50 mg in oil) administered once daily for 2 days.Serum P concentrations were measured in all groups.Concomitant food ingestion increased the area under the serum P concentration versus time curve (AUC0 to 24) and the maximum serum P concentration (Cmax) without affecting time to maximum serum concentration (Tmax) (P0.05). Micronized P absorption and elimination were first-order processes and exhibited dose-independent pharmacokinetics between 100 and 300 mg. After intramuscular P, Cmax was higher and Tmax occurred later compared with the oral P preparation. Oral P had lower relative bioavailability (8.6%) than intramuscular P.Absorption of micronized P was enhanced twofold in the presence of food. Both absorption and elimination were dose-independent, dose proportionality being confirmed. Bioavailability of the oral P was approximately 10% compared with intramuscular P. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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