| Autor: |
Guo-Ping, Li, Wan-Zi, Chen, Hui-Fang, Huang, Jia-Di, Chen, Xiao-Lan, Lin, Qiang, Fu |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 23(5) |
| ISSN: |
1009-2137 |
| Popis: |
To investigate the feasibility of CyclinD1/IgH detection by FISH in diferential diagnosis between mantle cell lymphoma (MCL) and chronic lymphocytic leukeamia (CLL).The FISH detection was performed for CyclinD1/IgH fusion gene. A comprehensive analysis was carried out for clinical features, such as age, sex , WBC count and lymphocyte count, the bone marrow morphology and immunohistochemical staining were carried for CyclinD1/IgH.It is often difficult to distinguish MCL from CLL by bone marrow morphology, when the cell morphology was not typical; there was no difference in age, sex, WBC count and lymphocyte count between MCL and CLL groups; 9 out of 52 patients were diagnosed as MCL, and the direction of CyclinD1/IgH by FISH was positive in 7 of 9 MCL, while 3 of the 7 patients were negative by immunohistochemical staining for CyclinD1.Detection of CyclinD1/IgH by FISH can be used as a specific and feasible method for differential diagnosis of mantle cell lymphoma from chronic lymphocytic leukeamia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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