Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease
| Autor: | M B, Bogdanov, O A, Andreassen, A, Dedeoglu, R J, Ferrante, M F, Beal |
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| Rok vydání: | 2001 |
| Předmět: |
Cerebral Cortex
Male Huntingtin Protein Microdialysis Brain Deoxyguanosine Nuclear Proteins Mice Transgenic Nerve Tissue Proteins DNA Corpus Striatum Mitochondria Mice Oxidative Stress Huntington Disease 8-Hydroxy-2'-Deoxyguanosine Models Animal Nerve Degeneration Animals Humans Female Oxidation-Reduction Biomarkers DNA Damage |
| Zdroj: | Journal of neurochemistry. 79(6) |
| ISSN: | 0022-3042 |
| Popis: | Mitochondrial dysfunction and oxidative damage may play a role in the pathogenesis of Huntington's disease (HD). We examined concentrations of 8-hydroxy-2-deoxyguanosine (OH(8)dG), a well-established marker of oxidative damage to DNA, in a transgenic mouse model of HD (R6/2). Increased concentrations of OH(8)dG were found in the urine, plasma and striatal microdialysates of the HD mice. Increased concentrations were also observed in isolated brain DNA at 12 and 14 weeks of age. Immunocytochemistry showed increased OH(8)dG staining in late stages of the illness. These results suggest that oxidative damage may play a role in the pathogenesis of neuronal degeneration in the R6/2 transgenic mouse model of HD. |
| Databáze: | OpenAIRE |
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