[Differences in the effects of piracetam and fenazepam in emotional stress caused by the spatial reversal of a habit]

Autor:	A N, Inozemtsev, T A, Voronina, L L, Pragina, I A, Krutikova, N A, Tushmalova
Rok vydání:	1996
Předmět:	Male Benzodiazepinones Conditioning Classical Drug Evaluation Preclinical Spatial Behavior Reversal Learning Piracetam Rats Benzodiazepines Anti-Anxiety Agents Escape Reaction Animals Nootropic Agents Stress Psychological
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 59(6)
ISSN:	0869-2092
Popis:	Emotional stress was caused in rats by changing the location of the gate in the shuttle chamber through which training had been accomplished in the previous experiments. The procedure led to disorder of the avoidance response (AR) and increase of intertrial responses (ITR). Phenazepam (0.1 mg/kg) prevented increase in the number of ITS. Piracetam (300 mg/kg) reduced the sharp growth of ISR but, in contrast to phenazepam, it provided a higher level of AR reproduction. The ISR were greater in piracetam than in phenazepam administration. The obtained results show that the suggested model allows the difference in the effects of piracetam and phenazepam to be disclosed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a2eee5e364068a294d1799de7ce4ae31 https://pubmed.ncbi.nlm.nih.gov/9181869 Zobrazit plný text záznamu