Metabolites of feprazone in man
| Autor: | H, Yamaguchi, J, Kubo, K, Sekine, T, Naruchi, Y, Hashimoto, R, Kato |
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| Rok vydání: | 1979 |
| Předmět: | |
| Zdroj: | Drug metabolism and disposition: the biological fate of chemicals. 7(5) |
| ISSN: | 0090-9556 |
| Popis: | Two male volunteers received 400 mg of nonlabeled feprazone, 1,2-diphenyl-3,5-dioxo-4-(3'-methyl-but-2'-enyl)pyrazolidine. Metabolites were extracted and isolated by chromatography on silica gel. Isolated metabolites were unchanged drug, E-1,2-diphenyl-3,5-dioxo-4-(3'-hydroxymethyl-but-2'-enyl)pyrazolidine, and feprazone (C4)-beta-glucuronide. Feprazone (C4)-beta-glucuronide was the main metabolite and it belongs to a novel type of conjugate, (C)-beta-glucuronide. |
| Databáze: | OpenAIRE |
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