Synchronous ovarian dysgerminoma and breast carcinoma in a patient with positive immunostain of BRCA1
| Autor: | G I, Băltătescu, M, Așchie, V, Sârbu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Ovarian Neoplasms
BRCA1 Protein Ovariectomy Carcinoma Breast Neoplasms Dysgerminoma Middle Aged Hysterectomy Immunohistochemistry Neoplasms Multiple Primary Salpingectomy Mastectomy Modified Radical Treatment Outcome Humans Female Genetic Predisposition to Disease Tumor Suppressor Protein p53 Biomarkers Follow-Up Studies Neoplasm Staging |
| Zdroj: | Chirurgia (Bucharest, Romania : 1990). 108(2) |
| ISSN: | 1221-9118 |
| Popis: | Breast cancer is the most common malignant neoplastic process and the second cause of death for women. Ovarian cancer, despite having a lower incidence, represents an important cause of morbidity and mortality because it is usually discovered in advanced stages. The presence of both forms of cancer in a patient is associated with a high risk of BRCA1 gene mutations, which are responsible, together with BRCA2 gene mutations, for most of the breast and ovarian cancer family. Our case is special because it presents a synchronous and a rare association of a primary ovarian dysgerminoma (with an incidence of less than 1% of ovarian cancers) and a primary breast carcinoma in a patient of 46 years old. Immunohistochemical examination was performed using a panel of five biomarkers: oestrogen receptor, progesterone receptor, Herceptest, p53 and BRCA1. In our case, we identified a negative hormonal status and the absence of HER2/neu expression but a positive immuno-expression for p53 protein and BRCA1 protein. Postoperative course was favourable for the patient after each surgery, and she was discharged with the recommendation to perform a genetic counselling. |
| Databáze: | OpenAIRE |
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