| Autor: |
Vlad C, Sandulache, Laura J, Vandelaar, Heath D, Skinner, Juan, Cata, Katherine, Hutcheson, Clifton David, Fuller, Jack, Phan, Zuhair, Siddiqui, Stephen Y, Lai, Randal S, Weber, Mark E, Zafereo |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Headneck. 38 |
| ISSN: |
1097-0347 |
| Popis: |
The purpose of this study was to present our evaluation of the clinical and functional outcomes after salvage total laryngectomy (STL).We conducted a retrospective review of 218 patients who underwent STL between 1994 and 2014.Seventy percent of patients originally had T1 or T2, N0 tumors and 73% had definitive external-beam radiotherapy (EBRT) alone. A majority utilized tracheoesophageal prosthesis (77%) and were gastrostomy free (80%) at last follow-up. The 5-year disease control and overall survival (OS) rates were 65% and 57%, respectively. Patients with a disease-free interval after initial treatment2 years were more likely to develop a recurrence (p = .001) and die of disease (p = .032) after STL. The disease-free interval after EBRT impacted disease control (p.001), with 5-year disease control of 92% for5-year disease-free interval and 60% for2-year disease-free interval.Most patients remain disease-free after STL, achieve intelligible tracheoesophageal speech, and maintain an oral diet. Delayed recurrence after initial treatment portends better survival and may indicate a distinct biological profile. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1962-E1968, 2016. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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