| Popis: |
Literature on the influence of cyclic nucleotides on the mechanism o f action of various drugs is reviewed. Cyclic nucleotides seem to participate in all aspects of nervous activity and thus mediate the effects of drugs acting on the central nervous system. They also seem to have a role in the actions of drugs on the cardiovascular system, the gastrointestinal tract, smooth muscle activity, and the immune response. The drugs which are discussed whose effects may be mediated by cyclic nucleotides include morphine, apomorphine, ethanol, local anesthetics, drugs affecting cardiac contractility, antihypertensive agents, drugs that reduce intraocular pressure, diuretics, anticancer and antiproliferation drugs, antiinflammatory agents, oral antidiabetic agents, muscle relaxants, carcinogenic agents, and contraceptive agents. |
