| Autor: |
C, Johanet, C, André, J, Sibilia, A, Baquey, F, Oksman, M, San Marco, R L, Humbel, M F, Taillefer, P, Chrétien, A, Escande, J, Cohen, A, Chevailler, J C, Monier, J, Goetz |
| Jazyk: |
francouzština |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
La Revue de medecine interne. 21(6) |
| ISSN: |
0248-8663 |
| Popis: |
Autoantibodies directed against the ribosomal P proteins, P0, P1 and P2 (anti-P), have been related to lupus-related psychosis and/or depression. The diagnostic value of antibodies directed against other ribosomal proteins or 28S RNA (anti-no-P) remains unknown. A multicenter study including ten centers belonging to the study group for autoimmune diseases (GEAI) was conducted in order to determine the diagnostic value of anti-P and anti-no-P antibodies in a large population of patients.The patients were selected on the basis of the presence of serum anti-ribosomal antibodies detected by indirect immunofluorescence (IF) on rat liver/kidney/stomach/pancreas sections and human HEp2 cells. The clinical course of all patients was studied using a predetermined survey. The specificity of anti-P antibodies were determined by Western blot.Anti-ribosomal antibodies were found in 82 patients. Fifty-five of them had systemic lupus erythematosus and 27 had another disease. Only 54% of the anti-ribosomal antibodies detected by IF were anti-P and were found in 69% of the patients with systemic lupus erythematosus. Anti-no-P antibodies (46%) were preferably detected in patients who suffered from another disease (78%). In patients with systemic lupus erythematosus, neurological and psychiatric disorders were more frequent in the no-P group (47% vs. 16%, P0.01) than arthritis, which was found more frequently in the P group (78% vs. 53%, P0.05).Anti P antibodies do not constitute a specific diagnostic marker of systemic lupus erythematosus, and lupus-related neuropsychiatric disorders would be preferably associated with the presence of anti no-P antibodies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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