Polyvinyl alcohol-methyl acrylate copolymers as a sustained-release oral delivery system

Autor:	R C, DiLuccio, M A, Hussain, D, CoffinBeach, G, Torosian, E, Shefter, A R, Hurwitz
Rok vydání:	1989
Předmět:	Dogs Acrylates X-Ray Diffraction Polymers Delayed-Action Preparations Polyvinyl Alcohol Phenylpropanolamine Animals Biological Availability Female Crystallization Half-Life Tablets
Zdroj:	Pharmaceutical research. 6(10)
ISSN:	0724-8741
Popis:	Low crystalline and crystalline polyvinyl alcohol-methyl acrylate (PVA-MA) copolymers were examined, because of their excellent flow and compressibility properties, as matrices for sustained-release tablets using phenylpropanolamine hydrochloride (PPA.HCl) as a model drug. Crystallinity of the copolymer affected the release characteristics from the tablet. Tablets made with low-crystalline PVA-MA provided sustained release of PPA, both in vitro and in vivo in dogs. PPA absorption from the low-crystalline PVA-MA tablet formulation was biphasic. An initial rapid phase was followed by a second, slower absorption phase which continued over 16 hr. Plasma PPA concentrations then declined with a half-life roughly parallel to the oral immediate-release half-lives. Oral bioavailability from the low-crystalline PVA-MA tablet formulation was 78.8 +/- 3.9%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a28243035eefe2fcaf48a94caa36509f https://pubmed.ncbi.nlm.nih.gov/2608626 Zobrazit plný text záznamu Full text from SpringerLink