| Autor: |
P G, Madonov, D N, Kinsht, K I, Ershov, M A, Shilova, O N, Solov'ev |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery. 21(1) |
| ISSN: |
1027-6661 |
| Popis: |
Recent years have witnessed an increased worldwide interest in medical use of unique naturally occurring enzymes - subtilisins possessing pronounced fibrinolytic and anti-inflammatory properties. The article deals with experience in clinical administration in vascular surgery of new therapeutic agent Thrombovasim® containing pegylated subtilisin as an active substance. Thrombovasim® has a favourable profile of safety, good tolerance and causes no severe haemorrhagic complications. The pharmacological action of Thrombovasim® consists in combination of the targeted effect on the fibrin carcass of the thrombus without participation of the own system of haemostasis and anti-inflammatory effect. In the Russian Federation Thrombovasim® has been used for 6 years predominantly in vascular pathology of lower limbs accompanied by the development of chronic venous insufficiency. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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