Synthesis, structures and biological activity of some 4-amino-3-cinnolinecarboxylic acid derivatives. Part 2
| Autor: | A, Stańczak, W, Lewgowd, Z, Ochocki, W, Pakulska, A, Szadowska |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Chemical Phenomena Spectrophotometry Infrared Chemistry Physical Carboxylic Acids Motor Activity Rats Lethal Dose 50 Amphetamine Mice Structure-Activity Relationship Seizures Animals Pentylenetetrazole Anticonvulsants Central Nervous System Stimulants Drug Interactions Female Rats Wistar Stereotyped Behavior Central Nervous System Agents |
| Zdroj: | Die Pharmazie. 52(2) |
| ISSN: | 0031-7144 |
| Popis: | 6,7,8-Substituted 4-amino-3-cinnolinecarboxylic acids 1 were condensed with amines to the corresponding 4-amino-3-cinnolinecarboxamides 7, 8. A variety of pharmacological tests showed a significant CNS activity of some new amides. Decarboxylation of 4-amino-3-cinnolinecarboxylic acids 1 yielded the corresponding 4-aminocinnolines 4 and alkaline hydrolysis of 1 gave 4-oxo-3-cinnolinecarboxylic acids 2. The acids 1 were converted into pyrimido[5,4-c]cinnolines 6 on two ways of synthesis. |
| Databáze: | OpenAIRE |
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