| Autor: |
T G, Landberg, L G, Håkansson, T R, Möller, W K, Mattsson, K E, Landys, B G, Johansson, D C, Killander, B F, Molin, P F, Westling, P H, Lenner, O G, Dahl |
| Rok vydání: |
1979 |
| Předmět: |
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| Zdroj: |
Cancer. 44(3) |
| ISSN: |
0008-543X |
| Popis: |
The effect of adjuvant combination chemotherapy when given to non-laparotomized patients in remission after radiotherapy in stage I or II non-Hodgkin's lymphoma was studied in a prospective randomized multicenter study. Locally extended field radiotherapy was given to a target absorbed dose of 40 Gy in 20 fractions. Fifty-five patients who were in complete remission 6 weeks after conclusion of radiotherapy were randomized to either no further therapy or to 9 cycles of CVP (cyclophosphamide + vincristine + prednisolone). The relapse-free survival at 30 months was 41% for patients without and 86% for patients with adjuvant chemotherapy (p = 0.02). The survival was the same for both treatment arms, being 90% at 30 months. Fifteen patients have relapsed, 14 of them with extensions and 1 with a recurrence within the radiation target volume. Analysis of subgroups showed that adjuvant chemotherapy in the present series significantly prolonged the relapse-free survival in diffuse histiocytic lymphoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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