[The effect of cocaine on binding of tricyclic antidepressives in the synaptic plasma membranes in the brain]

Autor: P, Bures, R, Krulík, Z, Fisar, K, Fuksová
Jazyk: čeština
Rok vydání: 1993
Předmět:
Zdroj: Ceskoslovenska psychiatrie. 89(5)
ISSN: 0069-2336
Popis: Effect of cocaine on binding of 3H-imipramine, 3H-desmethylimipramine, 3H-didesmethylimipramine and 3H-amitriptyline to brain synaptic plasma membranes (SPM) was studied. Binding of methylated tricyclic antidepressants was more affected. Cocaine inhibits 3H-imipramine binding at concentrations higher than 10(-5) mol/l. Binding stimulated by phosphatidylserine was affected more significantly.
Databáze: OpenAIRE