Synergistic Effect of Ceftazidime-Avibactam with Meropenem against Panresistant, Carbapenemase-Harboring
| Autor: | Juliana Januário, Gaudereto, Lauro Vieira, Perdigão Neto, Gleice Cristina, Leite, Roberta, Ruedas Martins, Gladys Villas, Boas do Prado, Flavia, Rossi, Thais, Guimarães, Anna Sara, Levin, Silvia Figueiredo, Costa |
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| Rok vydání: | 2018 |
| Předmět: |
Acinetobacter baumannii
Meropenem Microbial Sensitivity Tests biochemical phenomena metabolism and nutrition bacterial infections and mycoses Ceftazidime beta-Lactamases Anti-Bacterial Agents Drug Combinations Bacterial Proteins Susceptibility polycyclic compounds bacteria Azabicyclo Compounds Serratia marcescens |
| Zdroj: | Antimicrobial agents and chemotherapy. 63(5) |
| ISSN: | 1098-6596 |
| Popis: | Susceptibility of ceftazidime-avibactam and in vitro synergy with meropenem were investigated using disk approximation and time-kill assays against 11 multiresistant Acinetobacter baumannii isolates harboring oxacillinases and 5 Serratia marcescens isolates carrying bla(KPC-2). Ceftazidime-avibactam was very active and synergistic with meropenem against multiresistant S. marcescens isolates. On the other hand, only the A. baumannii isolates coharboring bla(OXA-23) and bla(OXA-117) displayed synergy. The disk approximation technique presented good sensitivity for synergism in S. marcescens infection. |
| Databáze: | OpenAIRE |
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