| Autor: |
M M, Yurinskaya, V A, Mit'kevich, M B, Evgen'ev, A A, Makarov, M G, Vinokurov |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Molekuliarnaia biologiia. 50(6) |
| ISSN: |
0026-8984 |
| Popis: |
The progress of neurodegeneration in Alzheimer's disease is closely associated with inflammatory processes in the brain tissues induced by beta-amyloid peptides (Aβ). In this paper, we showed that Aβ(1-42) and isoAβ(1-42) in human neuroblastoma cells SK-N-SH and promonocyte THP-1 activated the production of tumor necrosis factor (TNFα). Notably, isoAβ(1-42) had the strongest effect on the increase in the level of TNFα. The addition of recombinant heat-shock protein HSP70 reduces TNFα production induced by Aβ, which leads to a decrease in neuronal cell damage at the organism level. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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