| Autor: |
I O, Lisnjak, V V, Kutsenok, L Z, Polyschuk, O B, Gorobets, N F, Gamaleia |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Experimental oncology. 27(4) |
| ISSN: |
1812-9269 |
| Popis: |
To investigate the influence of photodynamic therapy (PDT) on the tumor angiogenesis and metastasis.The effect of PDT with a photosensitizer 5-aminolaevulinic acid (ALA) on tumor metastasis and angiogenesis was studied on the model of subcutaneously implanted Lewis lung carcinoma (3LL) in C57Bl/6 mice. VEGF level in blood serum of animals was evaluated by ELISA.It has been shown that application of ALA-PDT resulted in the lowered rate of metastatic spreading and decreased VEGF level in blood serum of 3LL-bearing mice, and morphologic alterations of vascular system in tumor tissue.The antitumor action of PDT using ALA as a photosensitizer is caused partly by antimetastatic and photodamaging effect mediated by vascularization disturbances in tumor tissue. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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