Increased Program Cell Death - 1 (PD-1) Expression on T Lymphocytes of Patients with Progressive Multifocal Leukoencephalopathy (PML)
| Autor: | Tan, Chen Sabrina, Bord, Evelyn, Broge, Thomas A, Glotzbecker, Brett, Mills, Heidi, Gheuens, Sarah, Rosenblatt, Jacalyn, Avigan, David, Koralnik, Igor J |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Aged 80 and over CD4-Positive T-Lymphocytes Male Immunity Cellular AIDS-Related Opportunistic Infections viruses Programmed Cell Death 1 Receptor Leukoencephalopathy Progressive Multifocal virus diseases HIV Infections CD8-Positive T-Lymphocytes Middle Aged JC Virus Article Young Adult Case-Control Studies Humans Female Aged |
| Popis: | The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4(+) and CD8(+) T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8(+) cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients. |
| Databáze: | OpenAIRE |
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