| Autor: |
S M, Ellerbroek, M S, Stack |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
BioEssays : news and reviews in molecular, cellular and developmental biology. 21(11) |
| ISSN: |
0265-9247 |
| Popis: |
Hematogenous metastasis is postulated to involve tumor cell-initiated degradation of basement membrane barriers and underlying connective tissue matrices. Matrix metalloproteinases (MMP) are zinc-dependent endopeptidases that have been implicated in the proteolytic events of tumor cell invasion. Research has revealed a class of membrane-anchored metalloproteinases (MT-MMPs) and has provided convincing evidence that these enzymes activate latent MMP-2 (72 kDa gelatinase A) on the cell surface. The activation of plasma membrane associated MMP is a potential mechanism for facilitation of cellular metastasis and requires consideration when addressing potential roles of MMPs in tumor progression. This review focuses on potential in vivo regulatory mechanisms of membrane-associated MMP activity in the context of tumor cell interaction with matrix macromolecules. BioEssays 1999;21:940-949. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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