[Alteration of telomere length of the peripheral white blood cells in patients with obstructive sleep apnea syndrome]

Autor:	Li, LIN, Tao-ping, LI
Rok vydání:	2011
Předmět:	Adult Male Sleep Apnea Obstructive Case-Control Studies Leukocytes Humans Female Middle Aged Telomere
Zdroj:	Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 31(3)
ISSN:	1673-4254
Popis:	To study the alteration of telomere length of the peripheral white blood cells in patients with obstructive sleep apnea syndrome (OSAS) and explore its significance.The DNA was extracted from the peripheral white blood cells of 11 patients with OSAS and 10 normal subjects matched for age and gender, and the T/S ratio was measured by fluorescence quantitative PCR.The T/S ratio in the peripheral white blood cells of patients with OSAS was obviously lower than that of the normal subjects (P0.05).The reduction in the telomere length in the peripheral blood cells suggests a possible relationship between OSAS pathogenesis and telomere length, and hypoxemia and hypercapnia make accelerate telomere shortening and promote cell apoptosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a14f53523cf7bf80a5201c29b5bd014e https://pubmed.ncbi.nlm.nih.gov/21421482 Zobrazit plný text záznamu