| Autor: |
J U, Holle, E, Reinhold-Keller, W L, Gross |
| Jazyk: |
němčina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Zeitschrift fur Rheumatologie. 71(9) |
| ISSN: |
1435-1250 |
| Popis: |
Granulomatosis with polyangitis (GPA, Wegener's granulomatosis) is characterized by a granulomatous inflammation of the respiratory tract and a necrotizing ANCA-associated small to medium-size vessel vasculitis with a predilection for the lungs (pulmonary capillaritis) and kidneys (necrotizing glomerulonephritis). The disease evolves stage-wise and typically starts as inflammation of the respiratory tract followed by development of systemic vasculitis manifestations. Today, treatment is evidence-based and adapted according to activity and disease stage which has resulted in a significant improvement in long-term outcome. Early mortality during the first year of treatment poses one of the main problems and is a result of infections under immunosuppressive treatment. Furthermore, treatment of refractory disease activity which is often represented by granulomatous manifestations is still a challenge and may result in significant organ damage if not treated successfully. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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