| Autor: |
Wawaimuli, Arozal, Emni, Purwoningsih, Hee Jae, Lee, Agian Jeffilano, Barinda, Abdul, Munim |
| Rok vydání: |
2021 |
| Zdroj: |
Frontiers in nutrition. 9 |
| ISSN: |
2296-861X |
| Popis: |
The cognitive deficit has frequently been found in the elderly population. Several studies have shown that every single part ofWe investigate whetherIn this study, 2 ml/kg body weight (BW) of MOO and 500 mg/kg BW of MOE were orally administered to the mice for 28 days, followed by intraperitoneal injection of Sco (1 mg/kg) at the day 22-28 to induce cognitive impairment in those mice.The Sco group showed memory retention impairment represented by the Y-maze and novel object recognition tests, significant enhancement of acetylcholine esterase (AChE) activity in hippocampus tissue (Our data reveal that MOO is preferable to MOE as a neuroprotective as evidenced by improving memory impairment. This effect, at least in part, through inhibiting the AChE and NF-κB activities and modulating the TrkB expression level. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
