AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type

Autor:	Chit, Chow, Angi Y, Liu, Wai S, Chan, Kenny I K, Lei, Wing Y, Chan, Anthony W I, Lo
Rok vydání:	2005
Předmět:	Interleukin-15 Killer Cells Natural Lymphoma Cell Survival Cell Line Tumor Nose Neoplasms Humans Interleukin-2 Phosphorylation Lymphoma T-Cell Immunohistochemistry Proto-Oncogene Proteins c-akt Immunophenotyping
Zdroj:	Haematologica. 90(2)
ISSN:	1592-8721
Popis:	Phosphorylated AKT has been detected in extranodal NK/T-cell lymphoma, nasal type (ENTL). Either interleukin-2 (IL-2) or interleukin-15 (IL-15) could prevent AKT dephosphorylation and apoptosis in the NK-92 cell line model. IL-15, but not IL-2, was preferentially elevated in patients' serum. AKT and IL-15 may be important in ENTL tumor survival.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a123b225420360f1bc1280e6d90b2a1c https://pubmed.ncbi.nlm.nih.gov/15710591 Zobrazit plný text záznamu