[Effect of new adenine derivative on emotional status of rats under conditions of 'voluntary alcoholization' model]

Autor:	D G, Kovalev
Rok vydání:	2011
Předmět:	Male Disease Models Animal Cognition Dose-Response Relationship Drug Depression Adenine Drug Evaluation Preclinical Animals Alcoholics Rats
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 74(3)
ISSN:	0869-2092
Popis:	In continuation of the study of pharmacological properties of the new drug VMA-99-82 (9-[2-(4-isopropylphenoxy)ethyl]adenine), the influence of this drug on the psycho-emotional status of rats was evaluated using a voluntary alcoholization model. It is established that VMA-99-82 administered at doses of 10 and 50 mg/kg produces a positive effect on impaired cognitive functions in alcoholized rats and eliminated the depression caused by the consumption of excess ethanol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a10502490ddf5596b3478f26c92d5dd7 https://pubmed.ncbi.nlm.nih.gov/21598628 Zobrazit plný text záznamu