Combined use of fractional exhaled nitric oxide and bronchodilator response in predicting future loss of asthma control among children with atopic asthma

Autor:	Je-Kyung, Kim, Jae-Yub, Jung, Heon, Kim, Sang-Yong, Eom, Youn-Soo, Hahn
Rok vydání:	2016
Předmět:	Hypersensitivity Immediate Male Bronchi Nitric Oxide Prognosis Asthma Bronchodilator Agents Breath Tests Predictive Value of Tests Forced Expiratory Volume Disease Progression Humans Female Child
Zdroj:	Respirology (Carlton, Vic.). 22(3)
ISSN:	1440-1843
Popis:	Recognition of patients at risk of asthma exacerbation is important for future asthma care and improved outcome. The aim of the present study was to see whether measurements of bronchodilator response (BDR) and fractional exhaled nitric oxide (FeNO) in combination provide prognostic information superior to either measurement alone in children with atopic asthma.A total of 201 atopic children aged 8-16 years with intermittent or mild persistent asthma were included. Pulmonary function tests including BDR and FeNO were serially monitored 10 times or more over 2 years when subjects were not receiving controller medications. After completion of monitoring, 1-year observation for a loss of asthma control was performed.During the monitoring period, positive BDRs (≥12% in forced expiratory volume in 1 s (FEVThese data support that combined use of BDR and FeNO measurements can modify predictive risk obtained from either measurement alone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a0f9bce11f43d7a024c4537f149565e0 https://pubmed.ncbi.nlm.nih.gov/27783458 Zobrazit plný text záznamu Plný text