| Autor: |
Remi, Kamakura, Ghulam Shere, Raza, Ermei, Mäkilä, Joakim, Riikonen, Miia, Kovalainen, Yoichi, Ueta, Vesa-Pekka, Lehto, Jarno, Salonen, Karl-Heinz, Herzig |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Molecular nutritionfood research. 66(4) |
| ISSN: |
1613-4133 |
| Popis: |
Nutrients stimulate the secretion of glucagon-like peptide-1 (GLP-1), an incretin hormone, secreted from enteroendocrine L-cells which decreases food intake. Thus, GLP-1 analogs are approved for the treatment of obesity, yet cost and side effects limit their use. L-cells are mainly localized in the distal ileum and colon, which hinders the utilization of nutrients targeting GLP-1 secretion. This study proposes a controlled delivery system for nutrients, inducing a prolonged endogenous GLP-1 release which results in a decrease food intake.α-Linolenic acid (αLA) was loaded into thermally hydrocarbonized porous silicon (THCPSi) particles. In vitro characterization and in vivo effects of αLA loaded particles on GLP-1 secretion and food intake were studied in mice. A total of 40.4 ± 3.2% of loaded αLA is released from particles into biorelevant buffer over 24 h, and αLA loaded THCPSi significantly increased in vitro GLP-1 secretion. Single-dose orally given αLA loaded mesoporous particles increased plasma active GLP-1 levels at 3 and 4 h and significantly reduced the area under the curve of 24 h food intake in mice.αLA loaded THCPSi particles could be used to endogenously stimulate sustain gastrointestinal hormone release and reduce food intake. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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