Hypochloremia as a novel adverse prognostic factor in acute liver failure

Autor: Jiexin, Wang, Po-Hong, Liu, Pin, Xu, Andrew, Sumarsono, Jody A, Rule, S Susan, Hedayati, William M, Lee
Rok vydání: 2022
Předmět:
Zdroj: Liver international : official journal of the International Association for the Study of the LiverREFERENCES. 42(12)
ISSN: 1478-3231
Popis: Emerging evidence has identified hypochloremia as an independent predictor for mortality in multiple conditions including cirrhosis. Acute liver failure (ALF) is frequently complicated by electrolyte abnormalities. We investigated the prognostic value of hypochloremia in a large cohort of ALF patients from North America.The Acute Liver Failure Study Group (ALFSG) registry is a longitudinal cohort study involving 2588 ALF patients enrolled prospectively from 32 North American academic centres. The primary outcome was a composite of 21-day all-cause mortality or requirement for liver transplantation (death/LT).Patients with hypochloremia (98 mEq/L) had a significantly higher 21-day mortality rate (42.1%) compared with those with normal (27.5%) or high (107 mEq/L) chloride (28.0%) (p .001). There was lower transplant-free cumulative survival in the hypochloremic group than in the normo- or hyper-chloremic groups (log-rank, χHypochloremia is a novel independent adverse prognostic factor in ALF. A new ALFSG-Cl Prognostic Index may improve the sensitivity to identify patients at risk for death without LT.
Databáze: OpenAIRE
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