Alkalinization of amide local anaesthetics by addition of 1% sodium bicarbonate solution

Autor:	Q J, Milner, B C, Guard, J G, Allen
Rok vydání:	2000
Předmět:	Epinephrine Temperature Titrimetry Lidocaine Alkalies Hydrogen-Ion Concentration Amides Bupivacaine Sodium Bicarbonate Chemical Precipitation Humans Ropivacaine Anesthetics Local Safety
Zdroj:	European journal of anaesthesiology. 17(1)
ISSN:	0265-0215
Popis:	A number of methods exist by which the pH of local anaesthetic solutions may be increased. Most commonly, these require the addition of differing amounts of sodium bicarbonate solution according to the local anaesthetic drugs. Sodium bicarbonate (1%) was titrated against pH in six commonly used local anaesthetic solutions. Titration curves of pH and volume of sodium bicarbonate solution added are shown for this group of local anaesthetics. This study demonstrates that 1 mL of 1% sodium bicarbonate solution may be used to alkalinize this range of local anaesthetics without the risk of precipitation. We also conclude that Ropivacaine (at concentration 0.75% and 1.0%), is unsuitable for alkalinization since it precipitates at a pH of 6.0.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a0b2dae78ab730c3c7e2bfd3ea32c90e https://pubmed.ncbi.nlm.nih.gov/10758442 Zobrazit plný text záznamu Plný text