Fetuin-A-containing calciprotein particle levels can be reduced by dialysis, sodium thiosulphate and plasma exchange. Potential therapeutic implications for calciphylaxis?

Autor:	Michael M X, Cai, Edward R, Smith, Catherine, Brumby, Lawrence P, McMahon, Stephen G, Holt
Rok vydání:	2014
Předmět:	Adult Plasma Exchange Renal Dialysis alpha-2-HS-Glycoprotein Calciphylaxis Thiosulfates Humans Female Middle Aged
Zdroj:	Nephrology (Carlton, Vic.). 18(11)
ISSN:	1440-1797
Popis:	Calciprotein particles (CPP) are a novel marker of mineral stress. High levels of CPP are found in patients with calciphylaxis, a condition associated with marked vascular calcification and a poor prognosis. We report substantial reductions in CPP levels in a dialysis patient having combined haemodialysis (HD) and plasma exchange (PEx) prior to an ABO-incompatible kidney transplant. We also report the effects of the same treatments combined with sodium thiosulphate (STS) in a patient newly diagnosed with calciphylaxis. Combining HD with intra-dialytic STS and PEx we achieved a significant reduction in CCP with the least rebound between treatment sessions. After 6 weeks of treatment, the CPP reduction was paralleled by clinical improvement. Measurement of CPP may be an attractive marker for monitoring the effectiveness of calciphylaxis therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a082c7c1cd207e7c39d6f8e53dcdd292 https://pubmed.ncbi.nlm.nih.gov/24571743 Zobrazit plný text záznamu Plný text