| Autor: |
M, Alecu, S, Alecu, G, Coman, E, Gălăţescu, C, Ursaciuc |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Roumanian archives of microbiology and immunology. 58(2) |
| ISSN: |
1222-3891 |
| Popis: |
The levels of ICAM-1, ELAM-1, TNF-alpha and IL-6 were determined in 12 patients with pemphigus vulgaris (PV) both in serum and the blister liquid. As a control, the same parameters were determined in 7 patients with herpes zoster (HZ). The patients with PV presented significantly higher values of ICAM-1 in the blister liquid, as compared to the serum values. The values of TNF-alpha and IL-6 were increased both in serum and the blister liquid. The ELAM-1 values did not show significant differences between serum and the blister liquid. In HZ patients, the blister liquid values did not significantly exceed the serum values both for ICAM-1 and ELAM-1. TNF-alpha and IL-6 presented high values both in serum and the blister liquid. We consider that the high values of ICAM-1 in the blister liquid from PV patients suggest the involvement of this adhesion molecule in the PV pathogenic features. The implication of ICAM-1 could be nonspecific and limited, and could possibly represent a reaction to the destruction of the desmosomal bonds within keratinocytes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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