| Autor: |
Elisa, Martín-Montañez, Maria José, Acevedo, Juan Félix, López-Téllez, Raymond Scott, Duncan, Antonio González, Mateos, José, Pavía, Peter, Koulen, Zafar U, Khan |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Neuroreport. 21(16) |
| ISSN: |
1473-558X |
| Popis: |
Calcium flux through L-type voltage-activated calcium (Cav1) channels is crucial for regulating brain functions including memory formation and behavior. Alterations in Ca2+ homeostasis have been linked to many cognitive disorders and understanding into the regulation of this process is crucial for their remedy. Therefore, here, we have evaluated the effect of a multifunctional protein known to be involved in memory functions called regulator of G protein signaling-14 (RGS-14) on Cav1 channel activity in neuronal cell lines NG108-15 and SH-SY5Y. RGS-14 protein produced significant reduction in Ca2+ influx in both cell lines and this effect was dependent on nifedipine-sensitive Cav1 channels. Thus, our results provide evidence supporting the idea that RGS-14 may facilitate the cognitive processing by modulating Cav1 channel-mediated intracellular Ca2+ transients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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