8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A

Autor:	Michał, Załuski, Jakub, Schabikowski, Piotr, Jaśko, Adrian, Bryła, Agnieszka, Olejarz-Maciej, Maria, Kaleta, Monika, Głuch-Lutwin, Andreas, Brockmann, Sonja, Hinz, Małgorzata, Zygmunt, Kamil, Kuder, Gniewomir, Latacz, Christin, Vielmuth, Christa E, Müller, Katarzyna, Kieć-Kononowicz
Rok vydání:	2020
Předmět:	Molecular Docking Simulation Structure-Activity Relationship Molecular Structure Humans Ligands Adenosine A2 Receptor Antagonists
Zdroj:	Bioorganic chemistry. 101
ISSN:	1090-2120
Popis:	A library of 34 novel compounds based on a xanthine scaffold was explored in biological studies for interaction with adenosine receptors (ARs). Structural modifications of the xanthine core were introduced in the 8-position (benzylamino and benzyloxy substitution) as well as at N1, N3, and N7 (small alkyl residues), thereby improving affinity and selectivity for the A
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a009e749db46e7c0188b2c8bdd165b6c https://pubmed.ncbi.nlm.nih.gov/32629282 Zobrazit plný text záznamu Full Text from ScienceDirect