Autoimmunity against the ryanodine receptor in myasthenia gravis

Autor:	G O, Skeie, P K, Lunde, O M, Sejersted, A, Mygland, J A, Aarli, N E, Gilhus
Rok vydání:	2001
Předmět:	Thymoma Myasthenia Gravis Animals Humans Autoimmunity Ryanodine Receptor Calcium Release Channel Thymus Neoplasms In Vitro Techniques Immunosuppressive Agents
Zdroj:	Acta physiologica Scandinavica. 171(3)
ISSN:	0001-6772
Popis:	Some myasthenia gravis (MG) patients have antibodies against skeletal muscle antigens in addition to the acetylcholine receptor (AChR). A major antigen for these antibodies is the Ca2+ release channel of the sarcoplasmic reticulum the ryanodine receptor (RyR). These antibodies are found mainly in MG patients with a thymoma MG and correlate with severe MG symptoms. The antibodies recognize a region near the N-terminus on the RyR, which seems to be of importance for RyR regulation. The antibodies cause allosteric inhibition of RyR function in vitro, inhibiting Ca2+ release from sarcoplasmic reticulum.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a00320d9ec8c49d43778d51c04e276e3 https://pubmed.ncbi.nlm.nih.gov/11412151 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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