| Autor: |
A, Breier, V, Durisová, R, Monosíková, T, Stankovicová, A, Vrbanová, V, Zúbor |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Bratislavske lekarske listy. 91(3) |
| ISSN: |
0006-9248 |
| Popis: |
Ca2+ ions cause marked inhibition of (Na+ + K+)-ATPase. Strontium and barium ions exert a less pronounced inhibition of (Na+ + K+)-ATPase activity. These findings suggest the existence of a regulatory binding site for calcium ions on the (Na+ + K+)-ATPase molecule. Under physiological conditions, this binding site is presumably involved in stopping the activity of (Na+ + K+)-ATPase during depolarization of the sarcolemma. In pathological conditions which are characterized by calcium overload of cardiomyocytes inhibition of (Na+ + K+)-ATPase by calcium ions can significantly contribute to massive damage of myocardial cells. (Fig. 3, Ref. 26.). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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