| Popis: |
The objective of this study was to prepare the liver targeting drug delivery system (TDDS) of artesunate (ART)-loaded polyethylene glycol (PEG)-poly(d,l-lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) modified by glycyrrhetinic acid (GA), and evaluate itsThe GA-PEG-PLGA-ART NPs enhanced theThe NPs were prepared using solvent evaporation method, and the formulation was optimized through an orthogonal design. In addition, physical properties were determined, including particle size, polydispersity index (PDI), zeta potential (ZP), morphology, drug loading capacity (LC) and encapsulation efficiency (EE), andThe GA-PEG-PLGA-ART NPs have spherical shape, small particle size (around 88 nm) with a narrow size distribution (PDI0.3), high drug LC (up to 59.3 ± 1.65%), and high EE (up to 73.13 ± 5.17%).The GA-PEG-PLGA-ART NPs appear as a potential liver targeted intracellular delivery platform for ART. |
