| Autor: |
G D, Trachiotis, T S, Johnston, J D, Vega, I R, Crocker, N, Chesnut, J F, Lutz, A L, Smith, K R, Kanter |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 17(11) |
| ISSN: |
1053-2498 |
| Popis: |
Nine heart transplant recipients were treated with single-field total lymphoid irradiation (TLI) for early (1 year) or late (1 year) rejection that was refractory to multiple regimens of immunosuppressive therapy. For patients with early rejection (n = 6), the rejection frequency (rejections/patient/month) decreased from pre-TLI of 1.63 to post-TLI of .02 (p.001), and for patients with late rejection (n = 3), the rejection frequency decreased from pre-TLI of .23 to post-TLI of .05 (p.02). The reduced rejection frequencies have been maintained for a mean follow-up of 28.6 (8 to 78) months, and adverse events during or late after TLI were uncommon. Single-field TLI is a safe and effective technique in the management of refractory rejection early or late after heart transplantation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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