Discriminative stimulus properties of ethanol in rats: studies on the role of nitric oxide
| Autor: | E, Koros, W, Kostowski, P, Bienkowski |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Indazoles Dose-Response Relationship Drug Ethanol Central Nervous System Depressants Nerve Tissue Proteins Nitric Oxide Synthase Type I Nitric Oxide Rats Discrimination Psychological NG-Nitroarginine Methyl Ester Animals Cues Enzyme Inhibitors Nitric Oxide Synthase Rats Wistar Injections Intraperitoneal |
| Zdroj: | Pharmacology, biochemistry, and behavior. 62(4) |
| ISSN: | 0091-3057 |
| Popis: | The present study examined the role of the L-arginine-nitric oxide pathway in mediation of the ethanol interoceptive (discriminative) cue. Adult male Wistar rats (n = 16) were trained to discriminate ethanol (1 g/kg, 10% v/v) from saline under a fixed-ratio 10 (FR10) schedule of sweetened milk reinforcement. A nonselective nitric oxide synthase (NOS) inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME; 10-540 mg/kg) did not substitute for ethanol. Similarly, a relatively selective neuronal NOS inhibitor, 7-nitroindazole (7-NI; 10-80 mg/kg), did not mimic the ethanol cue. However, both L-NAME and 7-NI produced significant reduction in the rate of operant responding. A nitric oxide precursor, L-arginine (100-500 mg/kg) neither substituted for nor antagonize the ethanol stimulus. Taken together, these results suggest that the L-arginine-nitric oxide pathway is not involved in mediation of the discriminative stimulus effects of ethanol in the rat. |
| Databáze: | OpenAIRE |
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