8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis
| Autor: | Joshua O, Odingo, Julie V, Early, Jake, Smith, James, Johnson, Mai A, Bailey, Megan, Files, Junitta, Guzman, Juliane, Ollinger, Aaron, Korkegian, Anuradha, Kumar, Yulia, Ovechkina, Tanya, Parish |
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| Rok vydání: | 2018 |
| Předmět: |
Microbial Viability
structure–activity relationship Molecular Structure Antitubercular Agents Hep G2 Cells Microbial Sensitivity Tests Mycobacterium tuberculosis Oxyquinoline Structure-Activity Relationship antibacterial tuberculosis Chlorocebus aethiops Hydroxyquinolines Animals Humans hydroxyquinoline Vero Cells Research Articles Research Article |
| Zdroj: | Drug Development Research |
| ISSN: | 1098-2299 |
| Popis: | There is an urgent need for new treatments effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. The 8‐hydroxyquinoline series is a privileged scaffold with anticancer, antifungal, and antibacterial activities. We conducted a structure–activity relationship study of the series regarding its antitubercular activity using 26 analogs. The 8‐hydroxyquinolines showed good activity against M. tuberculosis, with minimum inhibitory concentrations (MIC90) of 4 log kill at 10× MIC over 14 days. The majority of the compounds demonstrated cytotoxicity (IC50 of |
| Databáze: | OpenAIRE |
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