Enhanced expression of Fas-associated proteins in decidual and trophoblastic tissues in pregnancy-induced hypertension

Autor:	J M, Koenig, N, Chegini
Rok vydání:	2001
Předmět:	Fas Ligand Protein Membrane Glycoproteins Caspase 3 Placenta Pregnancy Complications Cardiovascular Trophoblasts Proto-Oncogene Proteins c-bcl-2 Pregnancy Caspases Proto-Oncogene Proteins Hypertension Decidua Humans Female fas Receptor bcl-2-Associated X Protein
Zdroj:	American journal of reproductive immunology (New York, N.Y. : 1989). 44(6)
ISSN:	1046-7408
Popis:	To determine if feto-placental tissues from gestations complicated by pregnancy-induced hypertension (PIH) have altered expression of Fas-associated proteins.The expression of several Fas-related proteins was determined in fetal membranes, decidua, and placentas obtained from PIH-affected (n = 12, age range 32-36 weeks) and normal (n = 6, age range 37-41 weeks) gestations. Paraffin-embedded tissue sections were stained with specific monoclonal antibodies to Fas, Fas ligand (FasL), caspase-3, and bax.We observed greater expression of Fas and FasL in amnion and decidua from PIH-affected gestations than in normal controls. Intense staining was observed only in the perivascular endothelium (caspase-3) and in decidual cells (bax) from PIH gestations.Differential expression of Fas-related proteins in fetal membranes, decidua, and placentas from PIH-affected gestations is consistent with increased apoptosis, and suggests activation of the Fas/FasL pathway in a tissue-specific manner.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9f68c5851a94c2fc437cc2752079dfd0 https://pubmed.ncbi.nlm.nih.gov/11200813 Zobrazit plný text záznamu Plný text