Traditional serrated adenoma of the colorectum: clinicopathologic implications and endoscopic findings of the precursor lesions
| Autor: | Mi-Jung, Kim, Eun-Jung, Lee, Jung-Pil, Suh, Sung-Min, Chun, Se-Jin, Jang, Do Sun, Kim, Doo Han, Lee, Suk Hee, Lee, Eui Gon, Youk |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adenoma
Adult Aged 80 and over Male Proto-Oncogene Proteins B-raf Class I Phosphatidylinositol 3-Kinases DNA Mutational Analysis Colonic Polyps Middle Aged Immunohistochemistry Polymerase Chain Reaction ErbB Receptors Proto-Oncogene Proteins p21(ras) Phosphatidylinositol 3-Kinases Ki-67 Antigen Proto-Oncogene Proteins ras Proteins Humans Female Endoscopy Digestive System Colorectal Neoplasms Precancerous Conditions Aged Oligonucleotide Array Sequence Analysis |
| Zdroj: | American journal of clinical pathology. 140(6) |
| ISSN: | 1943-7722 |
| Popis: | To investigate the clinicopathologic and endoscopic features of precursor lesions associated with traditional serrated adenomas (TSAs).Mutation studies for BRAF, KRAS, PIK3CA, and EGFR and immunohistochemical staining for Ki-67 were performed on 107 TSAs from 104 patients.Nondysplastic hyperplastic polyp (HP) or sessile serrated adenoma/polyp (SSA/P) precursor lesions were found in 56 (52.3%) TSAs, among which 32 (57.1%) cases showed a flat-elevated lesion with a type II pit pattern during endoscopy. TSAs with an SSA/P precursor lesion were usually found in the proximal colon, while TSAs with an HP or with no precursor lesion were mainly located in the distal colon and rectum (P.001). TSAs with a precursor lesion showed a lower frequency of conventional epithelial dysplasia and KRAS mutation as well as a higher frequency of BRAF mutation compared with those with no precursor lesion (P = .002, P.001, and P.001, respectively).A significant proportion of HP or SSA/P precursor lesions accompanied by TSAs can be detected by endoscopy based on both their flat-elevated growth and type II pit patterns. The heterogeneity of TSAs in terms of clinicopathologic and molecular features correlated with the status or type of precursor lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|