Does indomethacin for closure of patent ductus arteriosus affect cerebral function?

Autor:	A, Flisberg, I, Kjellmer, J, Löfhede, N, Löfgren, M, Rosa-Zurera, K, Lindecrantz, M, Thordstein
Rok vydání:	2010
Předmět:	Vasoconstriction Anti-Inflammatory Agents Non-Steroidal Indomethacin Infant Newborn Brain Humans Electroencephalography Ultrasonography Doppler Infusions Intravenous Ductus Arteriosus Patent Infant Premature
Zdroj:	Acta paediatrica (Oslo, Norway : 1992). 99(10)
ISSN:	1651-2227
Popis:	To study whether indomethacin used in conventional dose for closure of patent ductus arteriosus affects cerebral function measured by electroencephalograms (EEG) evaluated by quantitative measures.Seven premature neonates with haemodynamically significant persistent ductus arteriosus were recruited. EEG were recorded before, during and after an intravenous infusion of 0.2 mg/kg indomethacin over 10 min. The EEG was analysed by two methods with different degrees of complexity for the amount of low-activity periods (LAP, "suppressions") as an indicator of affection of cerebral function.Neither of the two methods identified any change in the amount of LAPs in the EEG as compared to before the indomethacin infusion.Indomethacin in conventional dose for closure of patent ductus arteriosus does not affect cerebral function as evaluated by quantitative EEG.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9f2a5a7206d693dcb6750291da910b30 https://pubmed.ncbi.nlm.nih.gov/20456268 Zobrazit plný text záznamu Plný text