| Autor: |
Xiao-Shu, Liu, Hui, Long, Yu-Xian, Huang, Jian-Hui, Xu, Jun-Yu, Zhu, Qing-Feng, DU, Bing-Yi, Wu |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 24(2) |
| ISSN: |
1009-2137 |
| Popis: |
To study the efficacy and safety of sorafenib combined with low dose cytarabine for treating patients with FLT3(+) relapsed and refractory acute myeloid leukemia (FLT3(+) RR-AML).Seven patients with FLT3(+) RR-AML were treated with sorafenib and low dose cytarabine. The curative rate and adverse effects were observed in these patients.Out of 7 RR-AML patients after treatment, 5 patients achieved complete remission (CR), 2 patients achieved partial remission (PR), and the overall response rate (ORR) after one course of therapy was 100%. No severe bleeding, nausea, vomiting and other side effects were found in these patients.Sorafenib combined with low dose cytarabine can effectively induce the remission of FLT3(+) RR-AML patients, and is worth for further clinical trails to verify its safty and efficiency. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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