[Recent advances in the treatment of type 1 diabetes mellitus]
| Autor: | N C, Schloot, M, Roden, S R, Bornstein, M D, Brendel |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Adolescent Genotype Cell Survival T-Lymphocytes Islets of Langerhans Transplantation Administration Oral Pilot Projects Diabetes Complications Young Adult Risk Factors Insulin-Secreting Cells Humans Hypoglycemic Agents Insulin Multicenter Studies as Topic Child Administration Intranasal Autoantibodies Hydrolysis Infant Receptors Interleukin-1 Milk Proteins Infant Formula Interleukin 1 Receptor Antagonist Protein Diabetes Mellitus Type 1 Child Preschool Pancreas Transplantation |
| Zdroj: | Deutsche medizinische Wochenschrift (1946). 136(5) |
| ISSN: | 1439-4413 |
| Popis: | INTERVENTIONAL APPROACHES TO BETA CELL PRESERVATION: In a pilot study, initial attempts at primary prevention by preserving islet beta cells have been successful with highly hydrolyzed milk formula in children who are at high genetic risk of diabetes. Attempts at secondary prevention by intranasal application in children with a high-risk HLA genotype and positive islet autoantibodies have been disappointing. But in tertiary prevention anti-inflammatory, antigen-directed and T-cell targeted treatment has been partially successful in slowing down the destruction of beta cells. BIOLOGICAL BETA CELL SUBSTITUTION: Transplantation of a vascularised pancreas or islet cells results in disease regression and the prevention of secondary/tertiary complications of diabetes. A principal aim is the avoidance of frequent, severe hypoglycaemic episodes resulting from markedly reduced awareness of hypoglycaemia or its counter-regulation. |
| Databáze: | OpenAIRE |
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