| Autor: |
V G, Nesterenko, Sh, Gruner, E I, Rubakova, A S, Babadzhanov |
| Rok vydání: |
1980 |
| Předmět: |
|
| Zdroj: |
Biulleten' eksperimental'noi biologii i meditsiny. 90(11) |
| ISSN: |
0365-9615 |
| Popis: |
Antireceptor antibodies anti- (CBA-anti-C57BL/6) and anti-(C57BL/6-anti-BALB/c) were obtained in a heterologous system by immunization of rabbits with alloimmune mouse lymphocytes and intensive absorption of immune rabbit sera. In the complement-dependent cytotoxic assay, these antireceptor antibodies were able to lyse only T-lymphoblasts with corresponding idiotypic specificity but not T-lymphoblasts of other idiotypes and normal T- and B- lymphocytes of various strains. It was also shown that antireceptor antibodies specifically inhibit the lethal graft-versus-host disease after injection of allogenic parental spleen cells into irradiated F1-recipients. These results suggest that heterologous antireceptor antibodies are capable of inhibiting specifically the immune responses to allogenic transplantation antigens. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
