Variation in the Use of Resection for Colorectal Cancer Liver Metastases
| Autor: | Hayley M, Fenton, John C, Taylor, J Peter A, Lodge, Giles J, Toogood, Paul J, Finan, Alastair L, Young, Eva J A, Morris |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Incidence Liver Neoplasms Kaplan-Meier Estimate Middle Aged Prognosis Risk Assessment Survival Analysis Disease-Free Survival United Kingdom Cohort Studies Logistic Models Editorial Hepatectomy Humans Female Neoplasm Invasiveness Registries Colorectal Neoplasms Colectomy Aged Neoplasm Staging Retrospective Studies |
| Zdroj: | Hepatobiliary Surg Nutr |
| ISSN: | 1528-1140 |
| Popis: | The aim of this study was to investigate variation in the frequency of resections for colorectal cancer liver metastases across the English NHS.Previous research has shown significant variation in access to liver resection surgery across the English NHS. This study uses more recent data to identify whether inequalities in access to liver resection still persist.All adults who underwent a major resection for colorectal cancer in an NHS hospital between 2005 and 2012 were identified in the COloRECTal cancer data Repository (CORECT-R). All episodes of care, occurring within 3 years of the initial bowel operation, corresponding to liver resection were identified.During the study period 157,383 patients were identified as undergoing major resection for a colorectal tumor, of whom 7423 (4.7%) underwent ≥1 liver resections. The resection rate increased from 4.1% in 2005, reaching a plateau around 5% by 2012. There was significant variation in the rate of liver resection across hospitals (2.1%-12.2%). Patients with synchronous metastases who have their primary colorectal resection in a hospital with an onsite specialist hepatobiliary team were more likely to receive a liver resection (odds ratio 1.22; 95% confidence interval, 1.10-1.35) than those treated in one without. This effect was absent in resection for metachronous metastases.This study presents the largest reported population-based analysis of liver resection rates in colorectal cancer patients. Significant variation has been observed in patient and hospital characteristics and the likelihood of patients receiving a liver resection, with the data showing that proximity to a liver resection service is as important a factor as deprivation. |
| Databáze: | OpenAIRE |
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